Stem cell study reveals astrocytes carrying the Alzheimer’s associated APOE4 gene release more cholesterol than those carrying the APOE3 gene. Findings shed light on how different versions of the APOE gene in astrocytes influence amyloid-beta productio…
Cholesterol produced by astrocytes in the brain is required for the production of amyloid-beta. The findings shed light on how and why amyloid-beta forms, and may explain why genes associated with cholesterol have been implicated as risk factors for Al…
Almost half of the identified human accelerated regions of the genome appear to act as neurodevelopment enhancers, researchers say. The findings shed new light on the genetic basis of human evolution.
A new advanced imaging technique shows how cholesterol regulates the production of Alzheimer’s associated amyloid beta proteins in astrocytes.
Hyperactive microglia immune cells may play a significant role in the development of ALS, researchers report.
Ketamine and exposure to 60-hertz flickering light show promise as a potentially new, non-invasive therapy to help rejuvenate the aging brain.
Study reveals the role astrocytes play in the crucial closing period of brain plasticity following birth. The findings could help in the development of strategies to reintroduce plasticity in the adult brain.
A new study reveals humans and mice have significant differences in how oxidative stress and inflammation trigger immune response genes in astrocytes. Researchers suggest lab models of neurodegeneration should incorporate specially engineered mouse mod…
The hepaCAM protein plays a critical role in the communication and coordination of astrocytes as they build synapses. The findings shed new light on potential biological mechanisms behind ASD and epilepsy.
Secondary infections and novel inflammatory events, even ones that occur external to the brain, amplify the brain’s immune response and detrimentally impact cognition in mouse models of Alzheimer’s disease.
The effects of intoxication, such as slurred speech and poor coordination, are a result of the breakdown of alcohol products in the brain and not the liver.
Astrocytes help transition the brain from a highly plastic state to one that is more stable.
Astrocytes influence how long, and how deeply, mice sleep, a new study reports.
Researchers investigate the role the blood-brain barrier may play in age-related memory problems.
Astrocytes derived from pluripotent stem cells of bipolar patients provide suboptimal support for neural activity. The malfunction can be traced to the inflammation-promoting molecule, interleukin-6.
Astrocytes in the striatum appear to play a critical role in stuttering. Researchers found treatment with risperidone helped reduce stuttering by increasing the metabolism of striatal astrocytes.
ApoE4, a gene associated with an increased risk of Alzheimer’s disease, also appears to increase susceptibility and the severity of COVID-19. SARS-CoV-2, the virus responsible for coronavirus, increased susceptibility to COVID-19 in ApoE4 neurons and a…
Post mortem tissue samples of people with depression revealed a lower number of astrocytes in the brain. The findings add to the growing body of literature that implicates astrocytes in depression pathology.
A newly discovered microbiome-controlled anti-inflammatory subset of astrocytes helps researchers better understand inflammation of the central nervous system and its regulation.
Astrocytes, not microglia, are responsible for constantly eliminate unnecessary and excessive adult synaptic connections in response to brain activity.