Researchers discovered mutations of the OPTN gene resulted in increased herpesvirus 1 growth in the brains of mice, leading to the death of local neurons. This resulted in accelerated neurodegeneration. OPTN deficiency was also associated with impairme…
New findings reinforce the idea that dementia with Lewy bodies can be pathologically classified as two different and distinct disease types.
A new mouse line makes the state of protein balance visible in the mammalian brain for the first time, allowing researchers to investigate disorders associated with protein misfolding.
Researchers have developed a new technique to quantify protein droplets associated with a range of neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and ALS.
Researchers reveal how proteins accumulate in the incorrect parts of brain cells in ALS, and demonstrate how it may be possible to reverse the accumulation.
Disruption of autophagy may be at the root of the cognitive deficits experienced by those with Huntington’s disease.
A new study reveals humans and mice have significant differences in how oxidative stress and inflammation trigger immune response genes in astrocytes. Researchers suggest lab models of neurodegeneration should incorporate specially engineered mouse mod…
NfL, a single biomarker in the blood, can accurately predict the presence of underlying neurodegenerative disorders, such as FTD and ALS, in people with cognitive problems.
A new study reports on an association between specific gut bacteria species and the manifestation of neurodegenerative disorders.
Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.
Study sheds light on what causes normal proteins to convert to a diseased form associated with CJD and Kuru.
Non-invasive focused ultrasound appears to be beneficial in the treatment of Parkinson’s disease for patients whose symptoms are poorly controlled by traditional medications.
Researchers find a previously unknown connection between ALS, FTD, and the Huntington’s disease associated gene, huntingtin.
Researchers have identified how specific genetic mutations cause ALS. The pathway, they believe, may also be responsible for the development of frontotemporal dementia.
In mouse models of Alzheimer’s disease, active neurons still encode memory, and a group of active neurons encodes novel environmental information. The signal of the novelty containing neurons causes a superimposition disturbing the signal of memory enc…
Repetitive negative thinking (RNT) in those aged over 55 is associated with an increased risk of cognitive decline and deposition of proteins associated with Alzheimer’s disease. People who exhibited higher levels of RNT experienced more cognitive and …
Females who attend school for longer have better memory ability in old age, a new study reports. For each year of education, memory gains were, on average, five times greater for women than the losses experienced due to each year of aging.
Changes in gut mucus may contribute to Alzheimer’s, Parkinson’s, and other neurological disorders. Researchers noted changes in types of gut mucus bacteria in those with a range of neurological disorders compared to their healthy peers. Findings sugges…
Tau spreads through the human brain via neural communication pathways. The spread is accelerated by the presence of amyloid-beta.
People with the Alzheimer’s associated ApoE e4e4 gene have increased vulnerability to developing severe symptoms of COVID-19 if they become infected with the virus. Findings suggest those with the dementia-related gene have double the risk of developin…