Schizophrenia itself is associated with loss of excitation, but hallucinations and other symptoms of the disorder are caused by a loss of synaptic inhibition.
Study identifies the main components driving amyloid beta-associated synaptic degeneration.
Study sheds new light on the role noncoded RNAs play at the synapse.
A new whole-genome sequencing study has revealed thirteen novel genes associated with Alzheimer’s disease. Researchers also found a new link between Alzheimer’s and synaptic function.
Findings shed new light on how the brain wires during development.
A new theory of memory visualizes the brain as an organic super-computer that runs complex binary code with neurons acting like mechanical computers. The theory is based on the discovery of the protein molecule, talin, which contains switch-like domain…
Over-expression of the synaptic protein RAPGEF2 drives synaptic loss associated with Alzheimer’s disease.
Prolonged anesthesia significantly alters the synaptic architecture of the brain, regardless of age.
A newly developed light-activated protein allows researchers to study single synapses of a neuron.
Gray matter damage associated with multiple sclerosis progression may be caused by inflammatory reactions that lead to synaptic loss.
Using a snap-freezing method, researchers have been able to reveal the true structure of the connections that join neurons together in the adult brain.
Researchers have developed a novel approach to measure the activity and strength of individual synapses that drive a neuron’s response to sensory input.
Astrocytes are involved in regulating inhibitory synapses by binding to neurons through the NrCAM adhesion molecule.
Astrocytes respond to cocaine exposure in the brains of mice by promoting the formation of new synapses.
Low-level exposure to lead during development does not lead to alcohol use disorder, but does alter the neural circuits in a way that if addiction occurs, it makes it harder to refrain from returning to addiction related behaviors.
A clusterization approach allows researchers to analyze dendritic spines in new ways.
The retrieval of mitochondria via a feedback loop is vital to sustaining synaptic transmission.
Researchers have identified a mechanism by which neurons communicate via intonations.
A newly designed synthetic compound could act as a prototype for a novel class of drugs to treat neurological damage.
When T helper cells are absent in the brain, microglia remain suspended between the fetal and adult developmental state. Mice lacking brain T cells showed changes in behavior and defective synaptic pruning. The study reveals the critical role T cells p…